Case study: Antibiotic-free industrial scale fermentation

Customer problem

  • Antibiotic-free gene maintenance for large scale fermentation manufacturing process
  • Reproduce customer productivity

Ingenza solution

  • Scalable bioprocess, independent of antibiotic selection
  • Target production meeting customer productivity and genetic stability specification
Host
  • Customer-specific E. coli host
  • Customer-specific growth protocol
Build/Test
  • Specific host auxotrophy introduced
  • Plasmid-based rescue of auxotrophy
  • No cross-feeding of plasmid free cells
Performance
  • Productivity meets customer benchmark
  • Antibiotic-free stability meets benchmark

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