Case study: Optimising gene design

Customer problem

  • Improved production of industrial biocatalyst in scalable bio-manufacturing host

Ingenza solution

  • 4x enhanced recombinant protein expression using Ingenza codon optimisation algorithm
  • Cost-effective / scalable B. subtilis biocatalyst manufacturing process, endotoxin-free
Host
  • B. subtilis host: GRAS, industrially scalable
  • No contamination of product with endotoxin
Promoter
Genewiz codon optimisation
Promoter
Twist codon optimisation
Promoter
Ingenza codon optimisation
Design/build
  • In-house codon optimisation to modulate expression of target
  • Compare to industry standards
Screen
  • Ingenza gene design algorithm outperforms industry standards
  • Maximises or minimises expression of target protein
Performance test
  • 4x activity versus customer benchmark
  • Cost-competitive production
  • Meets customer specifications

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